Mirabegron and Tamsulosin interaction
Mirabegron and Tamsulosin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Tamsulosin (Tamsulosin Hydrochloride) label · effective 2026-08-12
• Should not be used in combination with strong inhibitors of CYP3A4.
Tamsulosin hydrochloride capsules, 0.4 mg should not be used in combination with strong inhibitors of CYP3A4 (e.g., ketoconazole) [see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 )] .
• Tamsulosin hydrochloride capsules, 0.4 mg should not be used with strong inhibitors of CYP3A4 (e.g., ketoconazole).
…significant increase in tamsulosin exposure exists when tamsulosin hydrochloride capsules, 0.4 mg is coadministered with strong CYP3A4 inhibitors in CYP2D6 PMs, tamsulosin hydrochloride capsules, 0.4 mg should not be used in combination with strong inhibitors of CYP3A4 (e.g., ketoconazole) [see Warnings and Precautions ( 5.2 ) and Clinical Pharmacology ( 12.3 )] .
Use with caution in combination with moderate inhibitors of CYP3A4, with strong or moderate inhibitors of CYP2D6, in patients known to be CYP2D6 poor metabolizers, or in combination with other cytochrome P450 inhibitors.
From the Mirabegron (Myrbetriq) label · effective 2024-08-01
Drug interaction studies were conducted in adult patients to investigate the effect of coadministered drugs on the pharmacokinetics of mirabegron and the effect of mirabegron on the pharmacokinetics of coadministered drugs (e.g., ketoconazole, rifampin, solifenacin succinate, tamsulosin, and oral contraceptives) [see Clinical Pharmacology ( 12.3 )] .
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.