Mitapivat and Naloxegol interaction
Mitapivat and Naloxegol: the Naloxegol prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Naloxegol (MOVANTIK) label · effective 2026-09-01
Strong CYP3A4 inducers (e.g., rifampin) : Decreased concentrations of naloxegol; concomitant use is not recommended.
•Use with strong CYP3A4 inducers is not recommended .
CYP3A4 Inducers •Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.