Mitotane and Spironolactone interaction
Mitotane and Spironolactone: the Mitotane prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Mitotane (Lysodren) label · effective 2026-03-03
Spironolactone: Avoid concomitant use with LYSODREN.
Avoid concomitant use of mitotane with spironolactone [see Clinical Pharmacology (12.3) ].
Effects of Other Drugs on LYSODREN Spironolactone Spironolactone may block the action of mitotane.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.