Nafcillin and Piperacillin and tazobactam interaction
Nafcillin and Piperacillin and tazobactam: the Piperacillin and tazobactam prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Piperacillin and tazobactam (Piperacillin and Tazobactam and Sodium Chloride) label · effective 2026-05-08
Nephrotoxicity in critically ill patients has been observed; the use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients.
Nephrotoxicity in Critically Ill Patients The use of piperacillin and tazobactam was found to be an independent risk factor for renal failure and was associated with delayed recovery of renal function as compared to other beta-lactam antibacterial drugs in a randomized, multicenter, controlled trial in critically ill patients [see Adverse Reactions (6.1) ].
As with other penicillins, the administration of piperacillin and tazobactam may result in a false-positive reaction for glucose in the urine using a copper-reduction method (CLINITEST ® ).
As with other penicillins, piperacillin and tazobactam may cause neuromuscular excitability or seizures.
Central Nervous System Adverse Reactions As with other penicillins, piperacillin and tazobactam may cause neuromuscular excitability or seizures.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.