Nalmefene and Naloxegol interaction
Nalmefene and Naloxegol: the Naloxegol prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Naloxegol (MOVANTIK) label · effective 2026-09-01
Other opioid antagonists : Potential for additive effect and increased risk of opioid withdrawal; avoid concomitant use.
•Avoid use of MOVANTIK with another opioid antagonist.
Other Drug Interactions •Other opioid antagonists •Potential for additive effect of opioid receptor antagonism and increased risk of opioid withdrawal.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.