Nilotinib and Rifabutin interaction
Nilotinib and Rifabutin: the Nilotinib prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Nilotinib (CAVHANZA) label · effective 2026-08-07
Strong CYP3A Inducers: Avoid concomitant use with CAVHANZA.
Strong CYP3A Inducers Avoid concomitant use of strong CYP3A inducers with CAVHANZA.
Concomitant use with a strong CYP3A inducer decreases nilotinib exposure [see Clinical Pharmacology ( 12.3 )] which may reduce CAVHANZA efficacy.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.