Octreotide and Vitamin B12 interaction

Octreotide and Vitamin B12: the Octreotide prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Octreotide (Mycapssa) label · effective 2025-07-24

Moderate

Change in vitamin B12 levels: Monitor vitamin B 12 levels during treatment ( 5.6 ).

Warnings and precautionsnames Vitamin B12View label on DailyMed
Moderate

Changes in Vitamin B12 Levels Decreased vitamin B 12 levels and abnormal Schilling’s tests have been observed in some patients receiving octreotide.

Warnings and precautionsnames Vitamin B12View label on DailyMed
Moderate

Monitor vitamin B 12 levels during treatment with MYCAPSSA.

Warnings and precautionsnames Vitamin B12View label on DailyMed

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.