Omeprazole and Rifampin interaction
Omeprazole and Rifampin: the Omeprazole prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Omeprazole (Prilosec) label · effective 2024-03-19
John’s Wort or Rifampin : Avoid concomitant use of PRILOSEC.
John’s Wort, rifampin : Avoid concomitant use with PRILOSEC [see Warnings and Precautions ( 5.9 )] .
John’s Wort or rifampin) can substantially decrease omeprazole concentrations [see Drug Interactions ( 7 )] .
Table 4: Clinically Relevant Interactions Affecting Omeprazole When Co-Administered with Other Drugs CYP2C19 or CYP3A4 Inducers Clinical Impact: Decreased exposure of omeprazole when used concomitantly with strong inducers [see Clinical Pharmacology ( 12.3 )] .
John’s Wort or rifampin.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.