Paroxetine and Terbinafine interaction
Paroxetine and Terbinafine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Paroxetine (BRISDELLE) label · effective 2025-04-28
Cimetidine Increased plasma concentration of paroxetine Use caution if BRISDELLE is used concomitantly with other drugs that inhibit CYP2D6 (e.g., quinidine).
Potential for BRISDELLE to Affect Other Drugs Paroxetine is a strong CYP2D6 inhibitor.
From the Terbinafine (Terbinafine Hydrochloride) label · effective 2026-01-01
Drugs predominantly metabolized by the CYP450 2D6 isozyme include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flecainide and propafenone) and monoamine oxidase inhibitors Type B.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.