Pazopanib and Primidone interaction
Pazopanib and Primidone: the Pazopanib prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Pazopanib (VOTRIENT) label · effective 2025-12-16
VOTRIENT is not recommended if chronic use of strong CYP3A4 inducers cannot be avoided.
VOTRIENT is not recommended if chronic use of strong CYP3A4 inducers cannot be avoided [see Dosage and Administration (2.4)] .
Strong CYP3A4 Inducers : Consider an alternate concomitant medication with no or minimal enzyme induction potential.
Strong CYP3A4 Inducers Coadministration of strong CYP3A4 inducers may decrease plasma pazopanib concentrations.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.