Phenobarbital and Raltegravir interaction
Phenobarbital and Raltegravir: the Raltegravir prescribing label mentions this combination without an instruction to avoid it or change the dose.
Minor
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Raltegravir (ISENTRESS) label · effective 2026-07-13
Minor
The impact of other inducers of drug metabolizing enzymes, such as phenytoin and phenobarbital, on UGT1A1 is unknown.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.