Phenobarbital, hyoscyamine, atropine, and scopolamine and Trihexyphenidyl interaction
Phenobarbital, hyoscyamine, atropine, and scopolamine and Trihexyphenidyl: the Trihexyphenidyl prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Trihexyphenidyl (Trihexyphenidyl Hydrochloride) label · effective 2024-11-19
Trihexyphenidyl should be administered with caution in hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, alcoholics, those who have central nervous system disease, or those who do manual labor in a hot environment.
Drug Interactions Cannabinoids, barbiturates, opiates, and alcohol may have additive effects with trihexyphenidyl, and thus, an abuse potential exists.
Concurrent use of alcohol or other CNS depressants with trihexyphenidyl may cause increased sedative effects.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.