Pioglitazone and glimepiride and Sulfamethoxazole and trimethoprim interaction
Pioglitazone and glimepiride and Sulfamethoxazole and trimethoprim: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Pioglitazone and glimepiride label · effective 2025-12-12
Use in patients with known history of an allergic reaction to sulfonamide derivatives.
Hypersensitivity to sulfonamide derivatives.
Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations.
Strong CYP2C8 Inhibitors Pioglitazone An inhibitor of CYP2C8 (e.g., gemfibrozil) significantly increases the exposure (area under the serum concentration-time curve or AUC) and half-life (t ½ ) of pioglitazone.
Therefore, the maximum recommended dose of pioglitazone is 15 mg daily if used in combination with gemfibrozil or other strong CYP2C8 inhibitors.
From the Sulfamethoxazole and trimethoprim (SULFATRIM) label · effective 2026-09-02
Like other sulfonamide-containing drugs, sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.