Potassium chloride and Triamterene interaction
Potassium chloride and Triamterene: the Potassium chloride prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Potassium chloride label · effective 2026-01-01
Potassium chloride is contraindicated in patients on triamterene and amiloride.
Concomitant use with triamterene and amiloride ( 4 )
Triamterene and amiloride: Concomitant use is contraindicated ( 7.1 )
Triamterene or amiloride Use with triamterene or amiloride can produce severe hyperkalemia.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.