Prednisone and Sulfasalazine interaction
Prednisone and Sulfasalazine: the Prednisone prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Prednisone (Prednisone delayed release) label · effective 2026-04-30
NSAIDs including aspirin and salicylates: Increased risk of gastrointestinal side effects.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Including Aspirin and Salicylates Concomitant use of aspirin or other nonsteroidal anti-inflammatory drugs and corticosteroids increases the risk of gastrointestinal side effects.
The clearance of salicylates may be increased with concurrent use of corticosteroids; this could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.