Propylthiouracil and Sorafenib interaction
Propylthiouracil and Sorafenib: the Sorafenib prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sorafenib (Nexavar) label · effective 2023-08-28
• Impairment of Thyroid Stimulating Hormone Suppression (TSH) in DTC : Monitor TSH monthly and adjust thyroid replacement therapy in patients with thyroid cancer.
Monitor TSH levels monthly and adjust thyroid replacement medication as needed in patients with DTC.
Impairment of Thyroid Stimulating Hormone Suppression in Differentiated Thyroid Carcinoma NEXAVAR impairs exogenous thyroid suppression.
In the DECISION (DTC) study, 99% of patients had a baseline thyroid stimulating hormone (TSH) level less than 0.5 mU/L.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.