Protriptyline and Sevoflurane interaction
Protriptyline and Sevoflurane: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sevoflurane (Ultane) label · effective 2025-01-13
Consider having an anticholinergic and epinephrine available when administering sevoflurane for induction in this patient population.
In most cases, bradycardia improved with decreasing the concentration of sevoflurane, manipulating the airway, or administering an anticholinergic or epinephrine.
From the Protriptyline (Protriptyline Hydrochloride) label · effective 2023-07-25
Drug Interactions When protriptyline is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosages are required.
Protriptyline may enhance the response to alcohol and the effects of barbiturates and other CNS depressants.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.