Rabeprazole and Warfarin interaction
Rabeprazole and Warfarin: the Rabeprazole prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Rabeprazole (Aciphex) label · effective 2026-01-27
Use with Warfarin : Monitor for increases in INR and prothrombin time ( 5.2 , 7 ).
There have been reports of increased INR and prothrombin time in patients receiving a proton pump inhibitor and warfarin concomitantly.
Patients treated with ACIPHEX delayed-release tablets and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time [see Drug Interactions (7) ] .
Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs, including rabeprazole, and warfarin concomitantly.
Dose adjustment of warfarin may be needed to maintain target INR range.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.