Remifentanil and Succinylcholine interaction
Remifentanil and Succinylcholine: the Remifentanil prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Remifentanil (Ultiva) label · effective 2025-12-08
In the case of life-threatening muscle rigidity, a rapid onset neuromuscular blocker or naloxone may be administered.
Drug Interactions In animals the duration of muscle paralysis from succinylcholine is not prolonged by remifentanil.
Muscle rigidity occurring during the induction of anesthesia should be treated by the administration of a neuromuscular blocking agent and the concurrent induction medications and can be treated by decreasing the rate or discontinuing the infusion of ULTIVA or by administering a neuromuscular blocking agent.
The neuromuscular blocking agents used should be compatible with the patient's cardiovascular status.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.