Remifentanil and Trihexyphenidyl interaction
Remifentanil and Trihexyphenidyl: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Trihexyphenidyl (Trihexyphenidyl Hydrochloride) label · effective 2024-11-19
Drug Interactions Cannabinoids, barbiturates, opiates, and alcohol may have additive effects with trihexyphenidyl, and thus, an abuse potential exists.
Concurrent use of alcohol or other CNS depressants with trihexyphenidyl may cause increased sedative effects.
From the Remifentanil (Ultiva) label · effective 2025-12-08
It is responsive to ephedrine or anticholinergic drugs ( 5.8 )
Bradycardia Bradycardia has been reported with ULTIVA and is responsive to ephedrine or anticholinergic drugs, such as atropine and glycopyrrolate.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.