Rifapentine and Tolvaptan interaction
Rifapentine and Tolvaptan: the Tolvaptan prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Tolvaptan (SAMSCA) label · effective 2026-05-07
Avoid concomitant use of SAMSCA with strong CYP3A inducers.
Strong CYP3A Inducers Co-administration of SAMSCA with strong CYP3A inducers reduces exposure to SAMSCA [see Clinical Pharmacology (12.3) ] .
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.