Rifaximin and Warfarin interaction
Rifaximin and Warfarin: the Rifaximin prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Rifaximin (XIFAXAN) label · effective 2025-06-25
Warfarin: Monitor INR and prothrombin time; dose adjustment of warfarin may be needed to maintain target INR range.
Dose adjustment of warfarin may be needed to maintain target INR range.
Warfarin Changes in INR have been reported postmarketing in patients receiving rifaximin and warfarin concomitantly.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.