Sitagliptin and metformin and Tafenoquine interaction
Sitagliptin and metformin and Tafenoquine: the Tafenoquine prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Major
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Tafenoquine (Arakoda) label · effective 2025-01-10
Major
Avoid coadministration of ARAKODA with OCT2 and MATE substrates (e.g., dofetilide, metformin).
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.