Sulfamethoxazole and trimethoprim and Venlafaxine interaction
Sulfamethoxazole and trimethoprim and Venlafaxine: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sulfamethoxazole and trimethoprim (SULFATRIM) label · effective 2026-01-05
The efficacy of tricyclic antidepressants can decrease when coadministered with sulfamethoxazole and trimethoprim.
From the Venlafaxine (Venlafaxine Hydrochloride) label · effective 2025-01-31
CYP2C9 Venlafaxine did not inhibit CYP2C9 in vitro .
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.