Tolcapone and Tranylcypromine interaction
Tolcapone and Tranylcypromine: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Tranylcypromine (Tranylcypromine Sulfate) label · effective 2025-07-25
…Rasagiline Contraindicated a HR Reserpine Contraindicated a HR S-adenosyl-L-methionine (SAM-e) Contraindicated a SS Tapentadol Contraindicated a HR/SS Tetrabenazine Contraindicated a HR Tolcapone Use with caution d HR Tramadol Use with caution d SS; Increased seizure risk Tryptophan Contraindicated a SS * Some drugs in this table may also belong to groups listed in…
From the Tolcapone label · effective 2020-10-01
It is theoretically possible, therefore, that the combination of Tolcapone tablets and a non-selective MAO inhibitor (e.g., phenelzine and tranylcypromine) would result in inhibition of the majority of the pathways responsible for normal catecholamine metabolism.
For this reason, patients should ordinarily not be treated concomitantly with Tolcapone tablets and a non-selective MAO inhibitor.
It is difficult to determine if Tolcapone tablets played a role in the pathogenesis of these events because these patients received several concomitant medications affecting the central nervous system such as monoaminergic (i.e., MAO-I, tricyclic and selective serotonin reuptake inhibitors) and anticholinergic agents.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.