Kwas alendronowy: interakcje
Kwas alendronowy (Fosamax, Binosto), bisfosfonian: 85 udokumentowanych interakcji w indeksowanych przez nas etykietach FDA i kartach informacyjnych. Poważne: 1, umiarkowane: 66, niewielkie: 18, pary, dla których etykieta nie zgłasza istotnej interakcji: 0. Każda pozycja poniżej cytuje zdanie, na którym się opiera. Ta strona leku to punkt wyjścia, a nie rozstrzygnięcie dla indywidualnej sytuacji.
Jak wygląda lek Kwas alendronowy
Wszystkie wersje (14)Wizualizacje na podstawie opisów produktów w etykietach FDA: kolor, kształt, rozmiar i oznaczenie. 14 udokumentowanych wersji od 13 firm.
Interakcje z etykiety
Poważne interakcje (1)
Pamidronate disodium is contraindicated in patients with hypersensitivity to pamidronate disodium, other bisphosphonates, or mannitol. (etykieta leku Kwas pamidronowy, Przeciwwskazania)
Umiarkowane interakcje (66)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Aspirin In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Aspirin In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
The risk of GI hemorrhage may be increased when administering Exjade in combination with drugs that have ulcerogenic or hemorrhagic potential, such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, oral bisphosphonates, or anticoagulants. (etykieta leku Deferazyroks, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Closely monitor for signs of renal toxicity when XELODA is used concomitantly with nephrotoxic drugs (e.g. platinum salts, irinotecan, methotrexate, intravenous bisphosphonates). (etykieta leku Kapecytabina, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Aspirin In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Aspirin In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] . (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] . (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] . (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Suplementy i leki zobojętniające kwas żołądkowy zawierające magnez zmniejszają wchłanianie tych leków; dawki należy rozdzielić odstępem co najmniej dwóch godzin. (NIH Office of Dietary Supplements, Magnesium)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Oxybutynin chloride extended-release tablets should be used with caution in patients who have gastroesophageal reflux and/or who are concurrently taking drugs (such as bisphosphonates) that can cause or exacerbate esophagitis. (etykieta leku Oksybutynina, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Aspirin In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of alendronate sodium greater than 10 mg and aspirin-containing products. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] . (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
- SunitynibUmiarkowana
Concomitant exposure to other risk factors, such as bisphosphonates or dental disease/invasive dental procedures, may increase the risk of ONJ. (etykieta leku Sunitynib, Ostrzeżenia i środki ostrożności)
Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] . (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] . (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Use caution when co-prescribing aspirin/nonsteroidal anti- inflammatory drugs that may worsen gastrointestinal irritation. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
…osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Wapń wiąże te leki w jelicie i może znacznie ograniczyć wchłanianą ilość; dawki należy rozdzielić w czasie. (NIH Office of Dietary Supplements, Calcium)
Żelazo wiąże te leki w jelicie i zmniejsza ich wchłanianie; dawki należy rozdzielić w czasie. (NIH Office of Dietary Supplements, Iron)
Wzmianki o niewielkim znaczeniu (18)
Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Concomitant use of bisphosphonates, vitamin D supplementation, and calcium was not allowed. (etykieta leku Eksemestan, Ostrzeżenia i środki ostrożności)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Upper Gastrointestinal Adverse Reactions BINOSTO, like other bisphosphonates administered orally, may cause local irritation of the upper gastrointestinal mucosa. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Upper Gastrointestinal Adverse Reactions BINOSTO, like other bisphosphonates administered orally, may cause local irritation of the upper gastrointestinal mucosa. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Upper Gastrointestinal Adverse Reactions BINOSTO, like other bisphosphonates administered orally, may cause local irritation of the upper gastrointestinal mucosa. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (etykieta leku Kwas alendronowy, Ostrzeżenia i środki ostrożności)
Calcium supplements, antacids or oral medications containing multivalent cations interfere with absorption of alendronate. (etykieta leku Kwas alendronowy, Interakcje z innymi lekami)
Sprawdź, jak Kwas alendronowy łączy się ze wszystkim, co przyjmujesz. Dodaj całą listę; wszystkie pary są sprawdzane jednocześnie.
Otwórz w wyszukiwarceTo nie jest porada medyczna. Stopień nasilenia odzwierciedla sformułowania etykiety, a nie indywidualne okoliczności. Oznaczenie „poważna” może dotyczyć połączenia stosowanego rutynowo pod nadzorem, a „niewielka” może mieć znaczenie przy dużych dawkach. Należy zapytać farmaceutę.



