Cannabis (marijuana) interactions

THC adds to the sedation of many medicines and is metabolized by CYP enzymes that other drugs block or induce.

Cannabis (marijuana) has 7 documented interactions across the FDA labels and fact sheets we index: 0 major, 1 moderate, 6 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This tobacco and cannabis page is a starting point, not a verdict for your situation.

Moderate interactions (1)

  • Pantoprazoleproton pump inhibitorModerate

    False Positive Urine Tests for THC Clinical Impact: There have been reports of false positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving PPIs [see Warnings and Precautions (5.13) ] . (Pantoprazole label, Drug interactions)

Minor mentions (6)

  • Dexlansoprazoleproton pump inhibitorMinor

    False Positive Urine Tests for THC Clinical Impact: There have been reports of false positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving PPIs. (Dexlansoprazole label, Drug interactions)

  • DronabinolcannabinoidMinor

    Multiple Substance Abuse Patients with a history of substance abuse or dependence, including marijuana or alcohol, may be more likely to abuse dronabinol oral solution as well. (Dronabinol label, Warnings and precautions)

  • Esomeprazoleproton pump inhibitorMinor

    Intervention: Discontinue NEXIUM 4 weeks prior to testing [see Clinical Pharmacology (12.2) ] False Positive Urine Tests for THC Clinical Impact: There have been reports of false positive urine screening test for tetrahydrocannabinol (THC) in patients receiving PPIs. (Esomeprazole label, Drug interactions)

  • Lansoprazoleproton pump inhibitorMinor

    False Positive Urine Tests for THC Clinical Impact: There have been reports of false positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving PPIs. (Lansoprazole label, Drug interactions)

  • Omeprazoleproton pump inhibitorMinor

    False Positive Urine Tests for THC Clinical Impact: There have been reports of false positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving PPIs. (Omeprazole label, Drug interactions)

  • Rabeprazoleproton pump inhibitorMinor

    False Positive Urine Tests for THC Clinical Impact: There have been reports of false positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving PPIs. (Rabeprazole label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.