Melatonin interactions
Melatonin adds to drowsiness from sedating medicines and is cleared by the CYP1A2 enzyme.
Melatonin has 2 documented interactions across the FDA labels and fact sheets we index: 0 major, 2 moderate, 0 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This herbal and supplement page is a starting point, not a verdict for your situation.
Moderate interactions (2)
- Deferasiroxiron supplementModerate
Agents Metabolized by CYP1A2 Deferasirox inhibits CYP1A2 resulting in an increase in CYP1A2 substrate (e.g., alosetron, caffeine, duloxetine, melatonin, ramelteon, tacrine, theophylline, tizanidine) concentration when these drugs are coadministered. (Deferasirox label, Drug interactions)
- Tasimelteonsedative-hypnoticModerate
Beta-adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors. (Tasimelteon label, Drug interactions)
Check Melatonin against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.