Atenolol ve Diltiazem etkileşimi

(See DOSAGE AND ADMINISTRATION . ) Concomitant Use of Calcium Channel Blockers Bradycardia and heart block can occur and the left ventricular end diastolic pressure can rise when beta-blockers are administered with verapamil or diltiazem.

Because of its relative beta 1 selectivity, however, TENORMIN may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment.

Calcium channel blockers may also have an additive effect when given with TENORMIN (see WARNINGS ).

Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers.

Disopyramide is a Type I antiarrhythmic drug with potent negative inotropic and chronotropic effects.

Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction.

• Beta-blockers, digitalis, and other agents known to impair cardiac contractility and conduction may increase risk for hypotension, bradycardia, and heart failure.

Experience with the use of diltiazem in combination with beta-blockers in patients with impaired ventricular function is limited.