Karbamazepin ve Olanzapin etkileşimi

CNS Depressants The concomitant use of EQUETRO and other CNS depressants can increase the risk of respiratory depression, profound sedation, hypotension, and syncope.

Increased Intraocular Pressure Carbamazepine has mild anticholinergic activity.

Consider reducing the dose of CNS depressants or EQUETRO when using these drugs concomitantly.

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Carbamazepine: Increased clearance of olanzapine.

Higher daily doses of carbamazepine may cause an even greater increase in olanzapine clearance.

Inducers of CYP1A2 — Carbamazepine therapy (200 mg bid) causes an approximately 50% increase in the clearance of olanzapine.

This increase is likely due to the fact that carbamazepine is a potent inducer of CYP1A2 activity.

Inducers of CYP1A2 or Glucuronyl Transferase — Omeprazole and rifampin may cause an increase in olanzapine clearance.