Klopidogrel ve Esomeprazol etkileşimi

Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix [see Drug Interactions (7.1) ] .

Omeprazole or Esomeprazole Avoid concomitant use of Plavix with omeprazole or esomeprazole.

CYP2C19 inhibitors: Avoid concomitant use of omeprazole or esomeprazole.

A similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with Plavix.

Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of Plavix than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ] .

• Interaction with Clopidogrel: Avoid concomitant use of NEXIUM.

Interaction with Clopidogrel Avoid concomitant use of NEXIUM with clopidogrel.

Concomitant use of clopidogrel with 40 mg esomeprazole reduces the pharmacological activity of clopidogrel.

2C19 Substrates (e.g., clopidogrel, citalopram, cilostazol) Clopidogrel Clinical Impact: Concomitant use of esomeprazole 40 mg resulted in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition [see Clinical Pharmacology (12.3) ] .

There are no adequate combination studies of a lower dose of esomeprazole or a higher dose of clopidogrel in comparison with the approved dose of clopidogrel.