Fenobarbital ve Kinin etkileşimi

Drugs that Prolong the QT Interval : Avoid concomitant use.

QT Prolongation SEZABY may prolong the QT interval [see Clinical Pharmacology (12.2)] .

Drugs that Prolong QT Interval SEZABY may prolong the QT interval [see Warnings and Precautions (5.10) and Clinical Pharmacology (12.2)] .

Other products that may also prolong the QTc interval may have additive effects, and products that may increase concentrations of phenobarbital [see Drug Interactions (7.1)] may increase the QT prolongation risk; therefore, avoid concomitant use of SEZABY and these products.

If concomitant administration with carbamazepine or phenobarbital cannot be avoided, frequent monitoring of anticonvulsant drug concentrations is recommended.

The mean AUC increases of carbamazepine, phenobarbital and phenytoin were 104%, 81% and 4%, respectively; the mean increases in C max were 56%, 53%, and 4%, respectively.

Antiepileptics (AEDs) (Carbamazepine, Phenobarbital, and Phenytoin) Carbamazepine, phenobarbital, and phenytoin are CYP3A4 inducers and may decrease quinine plasma concentrations if used concurrently with quinine sulfate.

Anticonvulsants (Carbamazepine, Phenobarbital, and Phenytoin) A single 600 mg oral dose of quinine sulfate increased the mean plasma C max , and AUC 0–24 of single oral doses of carbamazepine (200 mg) and phenobarbital (120 mg) but not phenytoin (200 mg) in 8 healthy subjects.

Mean urinary recoveries of the three antiepileptics over 24 hours were also profoundly increased by quinine.