Prometazin ve dekstrometorfan ve Rasajilin etkileşimi

Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior.

Concomitant use of meperidine, tramadol, methadone, propoxyphene dextromethorphan, St.

Therefore, in view of rasagiline’s MAO inhibitory activity, dextromethorphan is contraindicated for use with rasagiline [see Contraindications ( 4 )] .

Dextromethorphan: Risk of psychosis or bizarre behavior ( 4 , 7.2 )

Dextromethorphan The concomitant use of rasagiline and dextromethorphan was not allowed in clinical studies.

Dextromethorphan should not be used in patients receiving a monoamine oxidase inhibitor (see PRECAUTIONS – Drug Interactions ).

Drug Interactions Monoamine Oxidase (MAO) Inhibitors – Hyperpyrexia, hypotension, and death have been reported coincident with the co-administration of monoamine oxidase (MAO) inhibitors and products containing dextromethorphan.

Thus, concomitant administration of Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution and MAO inhibitors should be avoided (see CONTRAINDICATIONS ).

Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAO inhibitors and phenothiazines are used concomitantly.