التداخل بين باراسيتامول وإيبوبروفين وتريبروستينيل

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.

In these patients, administration of a NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation.

This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis.

This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis.

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers.