التداخل بين أدينوزين وثيوفيلين

Use of methylxanthines (e.g., caffeine, aminophylline and theophylline) is not recommended in patients who experience a seizures in association with adenosine injection ( 5.6 )

Methylxanthine use is not recommended in patients who experience seizures in association with adenosine injection administration [see Overdosage (10) ].

Methylxanthines interfere with the activity of adenosine ( 7.1 , 10 )

Effects of Other Drugs on Adenosine Injection The vasoactive effects of adenosine are inhibited by adenosine receptor antagonists, (such as methylxanthines (e.g., caffeine, aminophylline, and theophylline).

Higher doses of adenosine may be required to achieve desired effect.

25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.

Clinically significant drug interactions with theophylline.* Drug Type of Interaction Effect** Adenosine Theophylline blocks adenosine receptors.