التداخل بين الكحول وداباغليفلوزين وميتفورمين

…concomitant use of certain drugs (e.g., carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, hepatic impairment and mitochondrial diseases [see Warnings and Precautions (5.1) ] .

• Risk factors include renal impairment, concomitant use of certain drugs, age >65 years old, radiological studies with contrast, surgery and other procedures, hypoxic states, excessive alcohol intake, hepatic impairment, and mitochondrial diseases.

Excessive Alcohol Intake: Alcohol potentiates the effect of metformin on lactate metabolism and this may increase the risk of metformin-associated lactic acidosis.

Precipitating conditions for diabetic ketoacidosis or other ketoacidosis include under-insulinization due to insulin dose reduction or missed insulin doses, acute febrile illness, reduced caloric intake, ketogenic diet, surgery, volume depletion, and alcohol abuse.

Alcohol Clinical Impact Alcohol is known to potentiate the effect of metformin on lactate metabolism.

الكحول قد يسبب انخفاض سكر الدم مع الإنسولين أو السلفونيل يوريا، والشرب بكثرة مع ميتفورمين يرفع خطر الحماض اللبني.

النص الأصلي للنشرة (بالإنجليزية) Alcohol can cause low blood sugar with insulin or sulfonylureas, and heavy drinking with metformin raises the risk of lactic acidosis.