التداخل بين الكحول وإيبويتين ألفا

…erythropoietin protein drugs [see Warnings and Precautions ( 5.6 )] Serious allergic reactions to Epogen [see Warnings and Precautions ( 5.7 )] Epogen from multiple-dose vials contains benzyl alcohol and is contraindicated in: Neonates, infants, pregnant women, and lactating women [see Warnings and Precautions ( 5.9 ), Use in Specific Populations ( 8.1 , 8.2 , 8.4 )] .

Use of the multiple-dose vials containing benzyl alcohol in neonates, infants, pregnant women, and lactating women ( 4 )

Risk of Serious Adverse Reactions Due to Benzyl Alcohol Preservative Epogen from multiple-dose vials contains benzyl alcohol and is contraindicated for use in neonates, infants, pregnant women, and lactating women [ see Contraindications ( 4 ) ] .

Serious and fatal reactions including “gasping syndrome” can occur in neonates and infants treated with benzyl alcohol-preserved drugs, including Epogen multiple-dose vials.

In addition, do not mix Epogen with bacteriostatic saline (which also contains benzyl alcohol) when administering Epogen to these patient populations [see Dosage and Administration ( 2 )] .