التداخل بين أليسكيرين وفوروسيميد

Monitor for changes in blood pressure and adjust the dose of other antihypertensive drugs if needed.

Furosemide: Oral coadministration of aliskiren and furosemide reduced exposure to furosemide.

Monitor diuretic effects when furosemide is coadministered with aliskiren.

Risk factors for the development of hyperkalemia include renal insufficiency, diabetes, combination use with ARBs or ACEIs [see Contraindications ( 4 ), Warnings and Precautions ( 5.2 ), and Clinical Studies ( 14.3 )] , NSAIDs, or potassium supplements or potassium sparing diuretics.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including selective Cyclooxygenase-2 inhibitors (COX-2 inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors with agents that affect the RAAS, including aliskiren, may result…