التداخل بين ألوبيورينول وكابيسيتابين

Capecitabine: Avoid concomitant use.

Intervention Avoid the use of allopurinol tablets during treatment with capecitabine Chlorpropamide Clinical Impact Allopurinol tablets prolongs the half-life of chlorpropamide as both compete for renal tubular excretion.

Drugs Known to Have Clinically Important Drug Interactions with Allopurinol Tablets Table 3: Interventions for Clinically Important Drug Interactions with Allopurinol Tablets Capecitabine Clinical Impact Concomitant use with allopurinol may decrease concentration of capecitabine’s active metabolites, which may decrease capecitabine efficacy.

Allopurinol: Avoid concomitant use of allopurinol with XELODA.

Avoid concomitant use of allopurinol with XELODA.

Effect of Other Drugs on XELODA Allopurinol Concomitant use with allopurinol may decrease concentration of capecitabine's active metabolites [see Clinical Pharmacology (12.3) ] , which may decrease efficacy.