التداخل بين ألوسيترون وكيتوكونازول

Ketoconazole increased mean alosetron plasma concentrations (AUC) by 29%.

Caution should be used when alosetron and ketoconazole are administered concomitantly.

CYP3A4 inhibitors: Use with caution in combination due to increased exposure of alosetron.

Coadministration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, voriconazole, and itraconazole has not been evaluated but should be undertaken with caution because of similar potential drug interactions.

In a pharmacokinetic study, 38 healthy female subjects received ketoconazole 200 mg twice daily for 7 days, with coadministration of alosetron 1 mg on the last day.