التداخل بين ألفيموبان ومورفين

Alvimopan capsules are contraindicated in patients who have taken therapeutic doses of opioids for more than 7 consecutive days immediately prior to taking alvimopan capsules [see Warnings and Precautions ( 5.3 )].

Patients who have taken therapeutic doses of opioids for more than 7 consecutive days prior to taking alvimopan capsules.

Alvimopan is contraindicated in patients who have taken therapeutic doses of opioids for more than 7 consecutive days immediately prior to taking alvimopan [see Contraindications ( 4) ].

Dosage adjustment for intravenously administered morphine is not necessary when it is coadministered with alvimopan.

Myocardial Infarction: A higher number of myocardial infarctions was reported in patients treated with alvimopan 0.5 mg twice daily compared with placebo in a 12-month study in patients treated with opioids for chronic non-cancer pain, although a causal relationship with long-term use has not been established.

Patient Access to an Opioid Overdose Reversal Agent for the Emergency Treatment of Opioid Overdose : Inform patients and caregivers about opioid overdose reversal agents (e.g., naloxone, nalmefene).