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Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status.

Monitor patients who are receiving levodopa for changes in neurological status during treatment with SEPHIENCE [see Drug Interactions ( 7.2 )] .

Interaction with Levodopa : Monitor patients for a change in neurologic status.

Effects of SEPHIENCE on Other Drugs SEPHIENCE may increase the availability of tyrosine, a precursor of levodopa.

Monitor patients for a change in neurologic status when levodopa is administered with SEPHIENCE [see Warnings and Precautions ( 5.3 )] .