التداخل بين أملوديبين وأتورفاستاتين وديسوجيستريل وإيثينيل إستراديول

Substances increasing the plasma concentrations of COCs: Co-administration of atorvastatin or rosuvastatin and certain COCs containing EE increase AUC values for EE by approximately 20 to 25%.

If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy.

• Oral Contraceptives: May increase plasma levels of norethindrone and ethinyl estradiol; consider this effect when selecting an oral contraceptive ( 7.5 ).

Atorvastatin Effects on Other Drugs Oral Contraceptives Clinical Impact: Co-administration of atorvastatin and an oral contraceptive increased plasma concentrations of norethindrone and ethinyl estradiol [see Clinical Pharmacology (12.3) ].

Intervention: Consider this when selecting an oral contraceptive for patients taking atorvastatin.