التداخل بين أملوديبين وأفانافيل

CYP3A4 Substrate When administered with avanafil 200 mg, amlodipine (5 mg daily) increased the C max and AUC of avanafil by approximately 22% and 70%, respectively.

The C max and AUC of amlodipine decreased by approximately 9% and 4%, respectively [see Dosage and Administration ( 2.3 )].

• Use of avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension ( 2.3 , 5.6 , 5.7 )

When vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased.

• Avanafil can potentiate the hypotensive effect of nitrates, alpha-blockers, antihypertensives, and alcohol ( 7.1 )