التداخل بين أبيكسابان وفيتوميناديون (فيتامين ك1)

For patients with APS (especially those who are triple positive [positive for lupus anticoagulant, anticardiolipin, and anti-beta 2-glycoprotein I antibodies]), treatment with DOACs has been associated with increased rates of recurrent thrombotic events compared with vitamin K antagonist therapy.

Protamine sulfate and vitamin K are not expected to affect the anticoagulant activity of apixaban.

Anticoagulants Phytonadione injectable emulsion may induce temporary resistance to prothrombin-depressing anticoagulants, especially when larger doses of phytonadione injectable emulsion are used.

Should this occur, higher doses of anticoagulant therapy may be needed when resuming anticoagulant therapy, or a change in therapy to a different class of anticoagulant may be necessary (i.e., heparin sodium).

Anticoagulants: May induce temporary resistance to prothrombin-depressing anticoagulants.

Phytonadione injectable emulsion does not affect the anticoagulant action of heparin.