التداخل بين أبريبيتانت ودوسيتاكسيل

Concomitant use of Docetaxel Injection and drugs that inhibit CYP3A4 may increase exposure to docetaxel and should be avoided.

In patients receiving treatment with Docetaxel Injection close monitoring for toxicity and a Docetaxel Injection dose reduction could be considered if systemic administration of a potent CYP3A4 inhibitor cannot be avoided [ see Dosage and Administration (2.7) , Clinical Pharmacology (12.3) ].

In vivo studies showed that the exposure of docetaxel increased 2.2-fold when it was coadministered with ketoconazole, a potent inhibitor of CYP3A4.

• Cytochrome P450 3A4 inducers, inhibitors, or substrates: May alter docetaxel metabolism.

Etoposide, vinorelbine, paclitaxel, and docetaxel No dosage adjustment needed.