التداخل بين أبريبيتانت وإيفوسفاميد

Intervention Vinblastine, vincristine, or ifosfamide or other chemotherapeutic agents Monitor for chemotherapeutic-related adverse reactions.

• CYP3A4 Inducers: Monitor for increased toxicity when used in combination with CYP3A4 inducers.

• CYP3A4 Inhibitors: Use in combination with CYP3A4 inhibitors could decrease the effectiveness of ifosfamide.

Inducers of CYP3A4 CYP3A4 inducers may increase the metabolism of ifosfamide to its active alkylating metabolites.

CYP3A4 inducers may increase the formation of the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde.

Closely monitor patients taking ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.