التداخل بين أبريبيتانت وأوميكليدينيوم وفيلانتيرول

Drug Interactions with Strong Cytochrome P450 3A4 Inhibitors Caution should be exercised when considering the coadministration of Umeclidinium and Vilanterol ELLIPTA with ketoconazole and other known strong cytochrome P450 3A4 (CYP3A4) inhibitors (including, but not limited to, ritonavir, clarithromycin, conivaptan, indinavir, itraconazole, lopinavir, nefazodone,…

• Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution.

Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to vilanterol.

Caution should be exercised when considering the coadministration of Umeclidinium and Vilanterol ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors [see Warnings and Precautions ( 5.4 ), Clinical Pharmacology ( 12.3 )] .

Inhibitors of Cytochrome P450 3A4 Vilanterol is a substrate of CYP3A4.