التداخل بين أتازانافير ورانيتيدين

Reduced plasma concentrations of atazanavir are expected if proton-pump inhibitors, antacids, buffered medications, or H 2 -receptor antagonists are administered with REYATAZ [see Dosage and Administration ( 2.3 , 2.4 , 2.5 and 2.6) ] .

H 2 - Receptor antagonists ↓ atazanavir Coadministration may result in loss of virologic response and development of resistance.

In HIV-treatment-naive adult patients: REYATAZ 300 mg with ritonavir 100 mg once daily with food should be administered simultaneously with, and/or at least 10 hours after, a dose of the H 2 -receptor antagonist (H2RA).

This can result in either an increase in absorption (e.g., triazolam, midazolam, glipizide) or a decrease in absorption (e.g., ketoconazole, atazanavir, delavirdine, gefitinib).

Atazanavir Atazanavir absorption may be impaired based on known interactions with other agents that increase gastric pH.

See atazanavir label for specific recommendations.