التداخل بين أتينولول وكلورثاليدون وسبيرونولاكتون وهيدروكلوروثيازيد

Concomitant administration of spironolactone and hydrochlorothiazide tablets with the following drugs or potassium sources may lead to severe hyperkalemia: • other potassium-sparing diuretics • ACE inhibitors • angiotensin II receptor antagonists • aldosterone blockers • non-steroidal anti-inflammatory drugs (NSAIDs), e.g., indomethacin • heparin and low molecular…

Thiazides may add to or potentiate the action of other antihypertensive drugs.

Because of its relative beta 1 -selectivity, however, atenolol and chlorthalidone may be used with caution in patients with bronchospastic disease who do not respond to or cannot tolerate, other antihypertensive treatment.

Drug Interactions Atenolol and chlorthalidone may potentiate the action of other antihypertensive agents used concomitantly.

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.

Other Precautions In patients receiving thiazides, sensitivity reactions may occur with or without a history of allergy or bronchial asthma.